Mouse histocompatibility-related genes are not conserved in other mammals.

AUTOR(ES)

Rogers, J H

RESUMO

In addition to the genes for classical H-2 antigens, the H-2 complex of the mouse contains numerous homologous genes belonging to several distinct families. It is not known whether they have any functions. To address this question, I have investigated whether these genes are separately conserved in evolution. Subcloned 5' gene segments, encoding the variable domains, were used as hybridisation probes on genomic DNA blots of various mammals. Only the largest gene family, which includes the classical H-2/HLA genes, is detectable in humans and other mammals. The other gene families, including Qa-2 and T1a, are not conserved even in rodents. Most or all of their coding sequences are therefore redundant.

Documentos Relacionados

• A highly conserved mouse gene with a propensity to form pseudogenes in mammals.
• A family of potassium channel genes related to eag in Drosophila and mammals.
• Protein binding sites are conserved in U1 small nuclear RNA from insects and mammals.
• Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals.
• Peroxisomal protein import is conserved between yeast, plants, insects and mammals.