Morphological and biochemical analysis of the synovia of rabbits immunized with type V collagen / "Análise morfológica e bioquímica da sinóvia de coelhos imunizados com colágeno do tipo V"

AUTOR(ES)

Luciana Tsuzuki Ichicawa Ogido

DATA DE PUBLICAÇÃO

2005

RESUMO

We described an original model of experimental synovitis in rabbits immunized with collagen V with scant cellular infiltration, intense matrix remodeling and vasculitis. Morphological and biochemical analysis were realized in New Zealand female rabbits (N=20) immunization with type V collagen, compared with control rabbits. It was observed increase of collagen I, III and V, vascular lumen occlusion and scant inflammatory process. Biochemical analysis confirmed the fibrosis with increased synthesis of collagen. We postulate that synovial changes described in this model are consequence of collagen V particularities, which promotes immunologic and clinical manifestations similar to scleroderma

ASSUNTO(S)

synovitis/chemically induced disease models animal coelhos colÁgenos fibrilares/análise fibrillar collagens/analysis rabbits modelos animais de doenÇas sinovite/induzido quimicamente

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