Monocyte-Derived Interleukin-10 Depresses the Bordetella pertussis- Specific Gamma Interferon Response in Vaccinated Infants▿
AUTOR(ES)
Dirix, V.
FONTE
American Society for Microbiology (ASM)
RESUMO
Antigen-specific gamma interferon (IFN-γ) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-γ after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-γ levels between individuals. We show here that the inhibition of the specific IFN-γ response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions −1082, −819, and −592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2786394Documentos Relacionados
- Interference of interleukin-10 with human immunodeficiency virus type 1 replication in primary monocyte-derived macrophages.
- Anoxia-hyperoxia induces monocyte-derived interleukin-8.
- Interferon-gamma inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages.
- Effects of Gamma Interferon, Interleukin-10, and Transforming Growth Factor β on the Survival of Mycobacterium avium subsp. paratuberculosis in Monocyte-Derived Macrophages from Naturally Infected Cattle
- Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages.
