Monitoring the fluidized bed granulation process based onS-statistic analysis of a pressure time series
AUTOR(ES)
Chaplin, Gareth
FONTE
Springer-Verlag
RESUMO
Pressure fluctuation measurements collected during the fluidized bed granulation of pharmaceutical granule have been analyzed using the attractor comparison technique denoted as theS-statistic. Divergence of the bed state from the reference during granulation is followed by a return to a condition statistically similar to the original state of the dry fluidized ingredients on drying. This suggests insensitivity of theS-statistic technique to the changes in particle size distribution occurring during the granulation process. Consequently, the monitoring of pressure fluctuations alone may provide an easily implemented technique for the tracking of granule moisture and process end-point determination.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2750532Documentos Relacionados
- Process analysis of fluidized bed granulation
- Monitoring Granulation Rate Processes Using Three PAT Tools in a Pilot-Scale Fluidized Bed
- Time series analysis of pressure fluctuation in gas-solid fluidized beds
- Size distribution of agglomerates of milk powder in wet granulation process in a vibro-fluidized bed
- Fluidized bed spray granulation: analysis of heat and mass transfers and dynamic particle populations
