Molecular Heterosis for Heat-Sensitive Enzyme Alleles
AUTOR(ES)
Singh, R. S.
RESUMO
Heat denaturation studies were carried out and revealed hidden genic variants with the same net charge at the Octanol dehydrogenase-1 locus in Drosophila pseudoobscura. Studies of several genetic crosses between strains with different heat-sensitivity alleles showed that the F1 retained more in vitro enzyme activity after being heat-treated for a specified amount of time at a given temperature than the heat-resistant parent. We call this phenomenon “heterosis for heat-stability of enzyme activity” and discuss its possible molecular mechanism, its relation to maintenance of genetic variation in natural populations, and its bearing on the “classical” and “balance” hypotheses.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=388330Documentos Relacionados
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