Molecular forms of butyrylcholinesterase and obesity
AUTOR(ES)
Boberg, Dellyana R., Furtado-Alle, Lupe, Souza, Ricardo L.R., Chautard-Freire-Maia, Eleidi A.
FONTE
Genetics and Molecular Biology
DATA DE PUBLICAÇÃO
23/07/2010
RESUMO
This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE gene. It was shown that obese and unobese individuals do not differ in the RI of each BChE band, even when classifying the sample into three genotypes of exons 1 and 4 of the BCHE gene (-116GG/539AA, -116GG/539AT, -116GA/539AT). Although the mean BChE activity of each band was significantly higher in obese than in unobese blood donors, the proportions of BChE bands were maintained, even under the metabolic stress associated to obesity, thereby leading to infer that this proportion is somehow regulated, and may therefore be important for BChE functions.
Documentos Relacionados
- Distributions of molecular forms of acetylcholinesterase and butyrylcholinesterase in nervous tissue of the cat.
- Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes
- Expedient Microwave-Assisted Synthesis of Bis(n)-lophine Analogues as Selective Butyrylcholinesterase Inhibitors: Cytotoxicity Evaluation and Molecular Modelling
- Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.
- Complete sequence of rabbit butyrylcholinesterase.