Molecular epidemiology of HIV-1 clades in Southern Brazil

Raboni, Sonia Mara, Almeida, Sérgio Monteiro de, Rotta, Indianara, Ribeiro, Cléa Elisa Lopes, Rosario, Debra, Vidal, Luine Rosele, Nogueira, Meri Bordignon, Riedel, Maristela, Winhescki, Maria da Graça, Ferreira, Kátia Antunes, Ellis, Ronald

Molecular epidemiology of HIV-1 clades in Southern Brazil

AUTOR(ES)

Raboni, Sonia Mara, Almeida, Sérgio Monteiro de, Rotta, Indianara, Ribeiro, Cléa Elisa Lopes, Rosario, Debra, Vidal, Luine Rosele, Nogueira, Meri Bordignon, Riedel, Maristela, Winhescki, Maria da Graça, Ferreira, Kátia Antunes, Ellis, Ronald

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2010-12

RESUMO

Human immunodeficiency virus (HIV) clades B and C account for more than 60% of the HIV-1 infections worldwide. In this paper, we describe the profiles of patients infected with subtypes of HIV-1 from the state of Paraná, Southern Brazil, and correlate them with demographic and epidemiological findings. A retrospective analysis of HIV cases reported from 1999-2007 was also performed. Data from 293 patients were reviewed and 245 were older than 13 (58% female). The distribution of clades was as follows: B 140 (57%), C 67 (23%), F 24 (10%) and mosaic or unique recombinant forms (URFs) 24 (10%). Of the 48 patients younger than 13 years of age (62.5% male), vertical transmission occurred in 46 and the distribution of clades was as follows: B 14 (29%), C 24 (50%), F 7 (15%) and URFs 6 (13%). There was no significant difference in mortality between HIV-1 subtypes. In both groups, patients infected with clade C tended to have higher rates of injection drug use exposure risk.