Molecular characterization of MHC-DRB cDNA in water buffalo (Bubalus bubalis)
AUTOR(ES)
Naskar, Soumen, Deb, Sitangsu M., Niranjan, Saket K., Kumar, Subodh, Sharma, Deepak, Sakaram, Durgam, Sharma, Arjava
FONTE
Genetics and Molecular Biology
DATA DE PUBLICAÇÃO
02/02/2012
RESUMO
In the present study, water buffalo MHC (Bubu)-DRB cDNA was cloned and characterized. The 1022 base long-amplified cDNA product encompassed a single open reading frame of 801 bases that coded for 266 amino acids. The Bubu-DRB sequence showed maximum homology with the BoLA-DRB3*0101 allele of cattle. A total of seven amino acid residues were found to be unique for the Bubu-DRB sequence. The majority of amino acid substitutions was observed in the β1 domain. Residues associated with important functions were mostly conserved. Water buffalo DRB was phylogenetically closer to goat DRB*A.
Documentos Relacionados
- Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
- INTOXICAÇÃO EM BÚFALOS (Bubalus bubalis) POR Baccharis megapotamica var. weirii
- Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
- Characterization of the DGAT1 gene in the Indian buffalo (Bubalus bubalis)
- Preliminary study on buffalo (Bubalus bubalis) milk production in Southern Brazil.
