Molecular biology of breast cancer metastasis: Genetic regulation of human breast carcinoma metastasis
AUTOR(ES)
Welch, Danny R
FONTE
BioMed Central
RESUMO
The present is an overview of recent data that describes the genetic underpinnings of the suppression of cancer metastasis. Despite the explosion of new information about the genetics of cancer, only six human genes have thus far been shown to suppress metastasis functionally. Not all have been shown to be functional in breast carcinoma. Several additional genes inhibit various steps of the metastatic cascade, but do not necessarily block metastasis when tested using in vivo assays. The implications of this are discussed. Two recently discovered metastasis suppressor genes block proliferation of tumor cells at a secondary site, offering a new target for therapeutic intervention.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138663Documentos Relacionados
- Molecular biology of breast cancer metastasis: Inflammatory breast cancer: clinical syndrome and molecular determinants
- Molecular biology of breast cancer metastasis: Clinical implications of experimental studies on metastatic inefficiency
- Molecular biology of breast cancer metastasis: 'Has it spread?': disarming one of the most terrifying questions
- Molecular biology of breast cancer metastasis: The use of mathematical models to determine relapse and to predict response to chemotherapy in breast cancer
- Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells