Modeling and Simulation of Pathways in Menopause
AUTOR(ES)
Tsavachidou, Dimitra
FONTE
American Medical Informatics Association
RESUMO
The analytical representation and simulation of complex molecular pathways can contribute to understanding and evaluating physiological as well as pathological processes. We are interested in modeling the processes of menopause to stratify women in terms of the genotypic and environmental components and their implications for development of individualized risk of postmenopausal disorders, e.g., breast and ovarian cancer, cardiovascular disease, and osteoporosis. We have initiated this study using the UltraSAN package to analyze the pathway associated with estrogen production. This model incorporates detailed information about the hormone factors affecting estrogen production, and the simulations carried out are based on published experimental data corresponding to hormone levels during the course of the normal female reproductive cycle. The agreement between the experimental data and the simulation is typically less than 2 ng/ml or 2 pg/ml respectively for progesterone and estradiol output. This approach further permits inclusion of information about an SNP observed in the gene coding for the enzyme aromatase as a model to study the impact of reduced enzymatic activity on hormone levels.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=346633Documentos Relacionados
- Modeling and simulation of direct contact evaporators
- Modeling and simulation of milk emulsion drying in spray dryers
- Aminoglycoside Nephrotoxicity: Modeling, Simulation, and Control
- Modeling and simulation of multi-component aerosol dynamics
- Modeling and Computer Simulation of Viscoelastic Crypt Deformation