Mitochondrial Telomeres as Molecular Markers for Identification of the Opportunistic Yeast Pathogen Candida parapsilosis

AUTOR(ES)

Nosek, Jozef

FONTE

American Society for Microbiology

RESUMO

Recent studies have demonstrated that a large number of organisms carry linear mitochondrial DNA molecules possessing specialized telomeric structures at their ends. Based on this specific structural feature of linear mitochondrial genomes, we have developed an approach for identification of the opportunistic yeast pathogen Candida parapsilosis. The strategy for identification of C. parapsilosis strains is based on PCR amplification of specific DNA sequences derived from the mitochondrial telomere region. This assay is complemented by immunodetection of a protein component of mitochondrial telomeres. The results demonstrate that mitochondrial telomeres represent specific molecular markers with potential applications in yeast diagnostics and taxonomy.

Documentos Relacionados

• Identification of Candida lusitaniae as an opportunistic yeast in humans.
• Torulopsis candida, a new opportunistic pathogen.
• Emergence of a new opportunistic pathogen, Candida lusitaniae.
• Candida zeylanoides: another opportunistic yeast.
• Hydrophobic surface protein masking by the opportunistic fungal pathogen Candida albicans.