Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect

AUTOR(ES)

Yang, G

FONTE

Nature Publishing Group

RESUMO

Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.

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