miR-141 is up-regulated in biopsies from Vietnamese patients with nasopharyngeal carcinoma
AUTOR(ES)
Lao, Thuan Duc, Nguyen, Truong Van, Nguyen, Dung Huu, Nguyen, Minh Trong, Nguyen, Chuong Hoang, Le, Thuy Huyen Ai
FONTE
Braz. oral res.
DATA DE PUBLICAÇÃO
17/12/2018
RESUMO
Abstract: Novel biomarkers for screening, diagnosis and monitoring the treatment of nasopharyngeal carcinoma (NPC), one of the most common cancers in Vietnam, are urgently required. Increasing evidence suggests that microRNA-141 (miR-141) is associated with NPC, owing to its ability to affect the expression of genes that modulate tumorigenesis. Unfortunately, research on miR-141 expression in Vietnamese patients is limited. Therefore, the objective of the current study was to evaluate miR-141 expression and assess whether miR-141 might be a potential biomarker for diagnosis of NPC in Vietnamese patients. Total RNA isolated from 40 NPC biopsy samples and 37 non-cancerous samples was analyzed by quantitative reverse-transcription PCR. The miR-141 expression levels were compared between NPC biopsy and non-cancerous samples. The frequency of miR-141 detection was 37.50% and 10.80% in the NPC and non-cancerous samples, respectively (p = 0.0143). The miR-141 expression was 5.27 times higher in tumor samples than non-cancerous samples. Additionally, the RR (Relative risk) and OR (Odds ratio) were 1.83 (95%CI = 1.2576–2.6675, p = 0.0016) and 4.95 (95%CI = 1.4625–16.7541, p = 0.01), respectively. In conclusion, miR-141 was up-regulated in the biopsy samples and thus may be a potential biomarker for NPC in the Vietnamese population.
Documentos Relacionados
- Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1
- Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury
- ACE2 gene expression is up-regulated in the human failing heart
- Expression of miR-155, miR-146a, and miR-326 in T1D patients from Chile: relationship with autoimmunity and inflammatory markers
- Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer