Microvessel density of spiral arteries in the placental bed in pregnancies complicated by preeclampsia. / Microdensidade Vascular no leito placentário em pacientes portadoras de Pré-eclâmpsia: estudo transversal descritivo comparativo

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

CONTEXT AND OBJECTIVE Morphological changes in the spiral arteries of the placental bed have been studied in patients with preeclampsia one of de most cause of maternal and perinatal morbidly and mortality. According to the reports, vasospasm and vascular endothelial injury are two major pathological conditions of preeclampsia. OBJECTIVE: The aim of the study was to investigate microvessel density of spiral arteries in the placental bed in pregnancies complicated by hypertension and proteinuria as well as in normal pregnancy. DESIGN AND SETTING: A cross-sectional survey of imunohistochemical study using CD 34, of placental bed biopsies containing spiral arteries based on women undergoing caesarean sections for clinical and obstetrical reasons performed at the Universidade Federal de São Paulo, São Paulo, Brazil. METHODS: Placental bed biopsies were obtained during caesarean section after placental removal, under direct visualization of central area of placental insertion and measurement of microvessel density spiral arteries by immunohistochemical in decidual and miometrial segments, using antibody CD34. RESULTS: Biopsies containing spiral arteries were obtained from 34 hypertensive pregnant women with proteinuria, and 26 normotensive pregnant women. Microvessel density in decidual and miometrial segments of placental bed was compared in both groups. It was observed that, with the increase of blood pressure and proteinuria, microvessel density dropped gradually. CONCLUSION: The presence and elevations of high levels of hypertension and proteinuria may

ASSUNTO(S)

1. pré-eclâmpsia. 2.proteinúria. 2.trofoblasto. 3.endotélio. 5.anticorpo cd 34. ginecologia e obstetricia preeclampsia. proteinuria. trophoblast. endothelium. antibody cd34.

ACESSO AO ARTIGO

Documentos Relacionados