Microvascular invasion is an independent prognostic factor in patients with prostate cancer treated with radical prostatectomy
AUTOR(ES)
Antunes, Alberto A., Srougi, Miguel, Dall’oglio, Marcos F., Crippa, Alexandre, Paranhos, Mario, Cury, Jose, Nesrallah, Luciano J., Leite, Katia R.
FONTE
International braz j urol
DATA DE PUBLICAÇÃO
2006-12
RESUMO
OBJECTIVE: Current published data regarding the prognostic value of microvascular invasion (MVI) in patients with prostate cancer (PCa) have yielded mixed results. Furthermore, most important series had surgical procedures performed by multiple surgeons and surgical specimens analyzed by multiple pathologists. We determined the relation of MVI with other pathologic features and whether this finding can be used as an independent prognostic factor in patients with PCa. MATERIALS AND METHODS: We selected 428 patients with clinically localized PCa treated with radical prostatectomy (RP). MVI was correlated to other pathologic features. The Kaplan-Meier method was used to evaluate survival curves and statistical significance was determined by the log-rank test. Multivariate analysis was performed through a Cox proportional hazards regression model. RESULTS: Eleven percent out of the 428 patients presented MVI. Except for the lack of association with biopsy Gleason score, MVI was related to all clinical and pathologic features of RP specimens. Mean follow up after surgery was 53.9 ± 20.1 months. Patients with MVI presented a recurrence rate of 44.6% compared to only 20.2% for patients without MVI (Log-rank test - p < 0.001). After Cox regression analysis, MVI was an independent prognostic feature related to biochemical recurrence. CONCLUSIONS: MVI is associated to advanced pathologic features of PCa and is an important prognostic factor regarding disease recurrence in patients treated with RP. These findings support the recommendations to the routine evaluation of this variable in pathologic reports of RP specimens.
Documentos Relacionados
- Socioeconomic status is an independent predictor of biochemical recurrence among patients with prostate cancer who undergo radical prostatectomy
- Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy
- Undergrading and understaging in patients with clinically insignificant prostate cancer who underwent radical prostatectomy
- Oncological outcomes following radical prostatectomy for patients with pT4 prostate cancer
- A new technique of bladder neck reconstruction during radical prostatectomy in patients with prostate cancer