Micronemal Transport of Plasmodium Ookinete Chitinases to the Electron-Dense Area of the Apical Complex for Extracellular Secretion
AUTOR(ES)
Langer, Rebecca C.
FONTE
American Society for Microbiology
RESUMO
Plasmodium ookinetes secrete chitinases to penetrate the acellular, chitin-containing peritrophic matrix of the mosquito midgut en route to invasion of the epithelium. Chitinases are potentially targets that can be used to block malaria transmission. We demonstrate here that chitinases of Plasmodium falciparum and P. gallinaceum are concentrated at the apical end of ookinetes. The chitinase PgCHT1 of P. gallinaceum is present within ookinete micronemes and subsequently becomes localized in the electron-dense area of the apical complex. These observations suggest a pathway by which ookinetes secrete proteins extracellularly.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=97734Documentos Relacionados
- Ultrastructural evidence concerning the mode of secretion of electron-dense granules by Clara cells.
- Small arrays of electron-dense cylinders in Escherichia coli cells.
- Electron-Dense Particles Resembling Ribosomes in Mesosomes of Bacillus subtilis
- Antigens in electron-dense granules from Entamoeba histolytica as possible markers for pathogenicity.
- Localization of electron-dense tracers during entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes.
