Mhc Class II DNA Polymorphisms within and between Chromosomal Species of the Spalax Ehrenbergi Superspecies in Israel

AUTOR(ES)

Ben-Shlomo, R.

RESUMO

Restriction fragment length polymorphisms (RFLPs) of two major histocompatibility class II genes (Pα(1) and Qβ) were studied in 13 populations of four chromosomal species (2n = 52, 54, 58 and 60) of the mole rat, Spalax ehrenbergi superspecies in Israel. A substantial frequency of allelic fragments was found in both genes for all populations, including a desert isolate. In the Pα(1) gene, one allelic fragment is a result of a deletion mutation which is diagnostic of the 2n = 52 chromosomal species. All other ten allelic variants are the result of point mutations. All mutations are located in a short region flanking the 3' end of the gene. Based on Mhc polymorphisms we confirm earlier evidence that gene flow does not occur between the older chromosomal species (2n = 52, 54, 58), and that reproductive isolation decreases, progressively from the oldest to the youngest species (2n = 60).

Documentos Relacionados

• Major histocompatibility complex gene organization in the mole rat Spalax ehrenbergi: evidence for transfer of function between class II genes.
• Circadian genes in a blind subterranean mammal II: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspecies
• Promoter accessibility within the environment of the MHC is affected in class II-deficient combined immunodeficiency.
• The common marmoset: A new world primate species with limited Mhc class II variability
• The lens protein alpha A-crystallin of the blind mole rat, Spalax ehrenbergi: evolutionary change and functional constraints.