METHOD DEVELOPMENT AND VALIDATION FOR THE FLUOROQUINOLONES DETERMINATION BY STABILIZED SILVER NANOPARTICLES
AUTOR(ES)
Moraes, Luiza D. de M.; Oliveira, André F. de; Teixeira, Alvaro V. N. de C.; Lopes, Renata P.
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2020-03
RESUMO
Silver nanoparticles (AgNPs) stabilized with glutathione (GSH) were used as nanosensors for the determination of fluoroquinolones such as ciprofloxacin (CIP), norfloxacin (NOR) and enrofloxacin (ENRO) in aqueous systems. The AgNPs were stabilized with GSH (Ag-GSH NPs), whereas the decrease of the surface plasmon resonance (SPR) band at 400 nm and the bathochromic shift of the absorption band were monitored. The method was validated and the analytical performance was verified. The results were satisfactory, with recoveries between 83.7 and 110% in almost all the experimental conditions and the repeatability and intermediate accuracy of less than 20%. The limits of detection were 0.397, 0.437 and 0.398 µmol L-1, and the limits of quantification were 1.203, 1.323 and 1.205 µmol L-1 for ciprofloxacin, norfloxacin and enrofloxacin, respectively. The method was selective in a group of drugs and applied in the determination of fluoroquinolones in potable water samples.
Documentos Relacionados
- Development and validation of an HPLC method for the determination of fluorouracil in polymeric nanoparticles
- DEVELOPMENT OF AN ANALYTICAL METHOD FOR THE DETERMINATION OF LEAD BASED ON LOCAL SURFACE PLASMON RESONANCE OF SILVER NANOPARTICLES
- A simple HPLC method for the determination of halcinonide in lipid nanoparticles: development, validation, encapsulation efficiency, and in vitro drug permeation
- DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR PALM OIL DETERMINATION IN MICROCAPSULES PRODUCED BY COMPLEX COACERVATION
- Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets