Metabolism of adrenal cholesterol in man: I. In vivo studies
AUTOR(ES)
Borkowski, Abraham
RESUMO
The kinetics of plasma and adrenal cholesteral equilibration were analyzed in patients undergoing bilateral adrenalectomy for generalized mammary carcinoma. A biological model is proposed to help in the understanding of adrenal cholesterol physiology. It comprises two intracellular compartments: (1) A compartment of free adrenal cholesterol which is small (of the order of 17 mg) but turns over very fast; it is renewed approximately 8 times per day: 3 times by the inflow of free plasma cholesterol, and 5 times by the hydrolysis of esterified adrenal cholesterol, the contribution of adrenal cholesterol synthesis appearing to be relatively small. (2) A compartment of esterified adrenal cholesterol which is 20 times larger; it is constantly renewed by in situ esterification and hydrolysis with a daily fractional turnover rate of the order of 0.25. The direct and selective accumulation of plasma cholesteryl esters is practically absent. Only free adrenal cholesterol returns to plasma, mostly after conversion into steroid “hormones.”
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=292314Documentos Relacionados
- Metabolism of adrenal cholesterol in man: II. In vitro studies including a comparison of adrenal cholesterol synthesis with the synthesis of the glucocorticosteroid hormones
- BODY CHOLESTEROL METABOLISM IN MAN. I. THE EQUILIBRATION OF SERUM AND TISSUE CHOLESTEROL*†
- Metabolism of steroid and amino acid moieties of conjugated bile acids in man: I. Cholylglycine
- Multicompartmental Analysis of Cholesterol Metabolism in Man: CHARACTERIZATION OF THE HEPATIC BILE ACID AND BILIARY CHOLESTEROL PRECURSOR SITES
- Elastic properties of muscles measured at the elbow in man: I. Normal controls.