Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

AUTOR(ES)

Liu, C., Wang, H., Liu, K.

FONTE

Braz J Med Biol Res

DATA DE PUBLICAÇÃO

04/07/2016

RESUMO

The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).

Documentos Relacionados

• Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis
• Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding
• A meta-analysis of efficacy and safety of doripenem for treating bacterial infections
• Efficacy of nimodipine in the treatment of subarachnoid hemorrhage: a meta-analysis
• Endoluminal thermal ablation versus stripping of the saphenous vein: Meta-analysis of recurrence of reflux