Mechanisms of K+ Transport in Isolated Turtle Urinary Bladder: INDUCTION OF ACTIVE K+ SECRETION IN A K+-ABSORBING EPITHELIUM
AUTOR(ES)
Husted, Russell F.
RESUMO
Transepithelial K+ movement was studied in vitro in the short-circuited turtle bladder by increasing luminal K+ permeability and by inhibiting the basolateral Na/K pump. Luminal addition of amphotericin B caused net K+ secretion (180±52 nmol/h) compared with net K+ absorption (42±6 nmol/h) in control bladders. Serosal ouabain and luminal amiloride abolished K+ secretion in amphotericin-treated bladders; ouabain restored net absorption (45±16 nmol/h). The direction and rate of net K+ transport are controlled by the relative K+ permeabilities and the Na/K pump sites at the two cell membranes of the epithelium.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=370291Documentos Relacionados
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