Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy
AUTOR(ES)
Lei, Hao
FONTE
National Academy of Sciences
RESUMO
Taking advantage of the high NMR detection sensitivity and the large chemical shift dispersion offered by ultra-high field strength of 7 T, the effect of magnetization transfer on inorganic phosphate (Pi) resonance during saturation of γ-ATP resonance, mediated by the ATP synthesis reaction, was observed noninvasively in the human primary visual cortex by using in vivo 31P magnetic resonance spectroscopy. The unidirectional flux from Pi to ATP was measured by using progressive saturation transfer experiments. The cerebral ATP synthesis rate in the human primary visual cortex measured by 31P magnetic resonance spectroscopy in this study was 12.1 ± 2.8 μmol ATP/g per min, which agreed well with the value that was calculated indirectly from the cerebral metabolic rate of glucose consumption reported previously.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283605Documentos Relacionados
- 31P magnetic resonance of tRNA.
- 31P Nuclear Magnetic Resonance Spectroscopy of Native and Recombined Lipoproteins
- Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy.
- Cardiac metabolism during exercise in healthy volunteers measured by 31P magnetic resonance spectroscopy
- Fructose-induced aberration of metabolism in familial gout identified by 31P magnetic resonance spectroscopy.
