Measles Virus Induces Functional TRAIL Production by Human Dendritic Cells

AUTOR(ES)

Vidalain, Pierre-Olivier

FONTE

American Society for Microbiology

RESUMO

Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway.

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