Mapmodulin: A possible modulator of the interaction of microtubule-associated proteins with microtubules
AUTOR(ES)
Ulitzur, Nirit
FONTE
The National Academy of Sciences of the USA
RESUMO
We have purified and characterized a 31-kDa protein named mapmodulin that binds to the microtubule-associated proteins (MAPs) MAP2, MAP4, and tau. Mapmodulin binds free MAPs in strong preference to microtubule-associated MAPs, and appears to do so via the MAP’s tubulin-binding domain. Mapmodulin inhibits the initial rate of MAP2 binding to microtubules, a property that may allow mapmodulin to displace MAPs from the path of organelles translocating along microtubules. In support of this possibility, mapmodulin stimulates the microtubule- and dynein-dependent localization of Golgi complexes in semi-intact CHO cells. To our knowledge, mapmodulin represents the first example of a protein that can bind and potentially regulate multiple MAP proteins.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=24635Documentos Relacionados
- High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain.
- Periodic crosslinking of microtubules by cytoplasmic microtubule-associated and microtubule-corset proteins from a trypanosomatid.
- Calcium lability of cytoplasmic microtubules and its modulation by microtubule-associated proteins
- Low molecular weight microtubule-associated proteins are light chains of microtubule-associated protein 1 (MAP 1).
- Two Microtubule-Associated Proteins of the Arabidopsis MAP65 Family Function Differently on Microtubules1