Mapeamento anátomo-funcional dos sítios neurais envolvidos nas respostas observadas durante exposição ao ambiente contextual de uma derrota social. / Anatomic and functional mapping of the neural sites involved in the observed responses during the exposition of the environment of a social defeat.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

28/08/2012

RESUMO

We investigated the neural systems involved in the contextual defense to a social defeat. We established a protocol to observe contextual defensive responses in animals previously defeated by an aggressive conspecific: animals were kept ten days living in a apparatus composed by two cages (room and resident cages). On the 11th day animals were exposed to an aggressive conspecific and defeated by it. On the following day, animals were exposed to the apparatus. These defeated animals presented defensive responses, characterized by risk assessment behaviors. Increased Fos expression was found in MEApd, LSr, elements of the social responsive medial hypothalamic circuit, the juxtadorsal part of the lateral hypothalamic area and the dorsal premammillary nucleus (PDMdm). The data allowed us to outline a putative circuit involved in the expression of contextual defense to social defeat, and indicates that both innate and contextual defense to social threat apparently share the same neural circuits.

ASSUNTO(S)

hypothalamus imunohistoquímica neurociências sistema nervoso animal behavior defensive comportamento defensivo animal hipotálamo immunohistochemistry nervous system neuroscience

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