Manganese in long term paediatric parenteral nutrition.

AUTOR(ES)

Reynolds, A P

RESUMO

The current practice of providing manganese supplementation to neonates on long term parenteral nutrition is leading to a high incidence of hypermanganesaemia. Magnetic resonance imaging (MRI) studies in adults on long term manganese parenteral nutrition have shown changes in TI weighted MRI images and similar findings in a neonate receiving trace element supplementation are reported here. Whole blood manganese concentration in the infant was 1740 nmol/l (or 8.3 times upper reference limit). In all neonates on long term parenteral nutrition with evidence of cholestatic liver disease so far investigated, the whole blood manganese concentrations were > 360 nmol/l (reference range 73-210). Manganese supplementation to patients on long term parenteral nutrition requires reappraisal, particularly in those who develop cholestatic liver disease associated with parenteral nutrition.

Documentos Relacionados

• Total parenteral nutrition.
• Use and abuse of parenteral nutrition.
• Candida lung abscesses complicating parenteral nutrition.
• Urea kinetics in neonates receiving total parenteral nutrition.
• Haemorrhagic thiamine deficient encephalopathy following prolonged parenteral nutrition.