Malabsorption of hemoglobin iron in pernicious anemia: correction with intrinsic factor—containing substances
AUTOR(ES)
Waxman, Samuel
RESUMO
Hemoglobin iron absorption in patients with treated prenicious anemia (PA) and concomitant iron deficiency was low compared to absorption in patients with iron deficiency alone. Crude and purified hog intrinsic factor (IF) concentrates doubled the absorption of hemoglobin iron in these patients as did normal (neutralized depepsinized) human gastric juice. Hemoglobin iron absorption was not significantly enhanced by PA gastric juice. Absorption of heme iron, like that of hemoglobin iron, was enhanced by normal neutralized depepsinized gastric juice. No enhancement of hemoglobin iron absorption by these substances was obtained in the normal or iron-deficient non-PA control subjects. Preincubation of the hog IF concentrate with antisera to IF significantly reduced the enhancement of hemoglobin iron absorption due to the concentrate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=297341Documentos Relacionados
- Biogenesis of von Willebrand factor-containing organelles in heterologous transfected CV-1 cells.
- ANTIBODY TO INTRINSIC FACTOR IN SERUM FROM PATIENTS WITH PERNICIOUS ANEMIA*
- Photoreactivation, Excision, and Strand-Rejoining Repair in R Factor-Containing Minicells of Escherchia coli K-12
- Impaired utilization of serum folate in pernicious anemia: A study with radiolabeled 5-methyltetrahydrofolate
- COMBINED CORD DEGENERATION WITHOUT ANEMIA: A CASE REPORT WITH STUDIES BEARING ON THE “INTRINSIC FACTOR” OF CASTLE