Lupus eritematoso neonatal: reporte de cuatro casos

AUTOR(ES)

Perez, Maria Fernanda, Torres, Maria Eugenia de, Buján, María Marta, Lanoël, Agustina, Cervini, Andrea Bettina, Pierini, Adrián Martín

FONTE

Anais Brasileiros de Dermatologia

DATA DE PUBLICAÇÃO

2011-04

RESUMO

Neonatal lupus erythematosus is a very rare disease, clinically characterized by skin lesions that resemble those of subacute or discoid lupus erythematosus and/or congenital heart block. Generally, when patients have skin manifestations, they have no cardiac defects and vice-versa; however, in 10% of cases these manifestations may coexist. Other findings may include hematologic, hepatic and neurological abnormalities. This condition is caused by the transplacental passage of maternal autoantibodies against Ro (95%), La and, less frequently, U1-ribonucleoprotein (U1-RNP). The present case report describes four patients with clinical, histopathological and immunological findings compatible with neonatal lupus erythematosus, their treatment and progress.

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