Long-term use of first-line highly active antiretroviral therapy is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients
AUTOR(ES)
Zhu, Haohui, Yuan, Jianjun, Wang, Yisa, Gao, Fan, Wang, Xiao, Wei, Changhua, Chen, Jiyun, Fan, Xiaohui, Zhang, Mei
FONTE
Braz J Infect Dis
DATA DE PUBLICAÇÃO
2014-09
RESUMO
Objective: To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China. Method: Fifty human immunodeficiency virus-positive patients with at least a 5-year history of highly active antiretroviral therapy use and 50 human immunodeficiency virus-positive patients without a history of highly active antiretroviral therapy use were enrolled in this study. Carotid artery intima-media thickness and stiffness were determined by quantitative inter-media thickness and quantitative artery stiffness, respectively. Results: No statistically significant difference in carotid artery intima-media thickness and stiffness was observed between groups. A significant association between human immunodeficiency virus infection time and carotid artery stiffness was observed, but no significant association between human immunodeficiency virus infection time and intima-media thickness was found. No significant association between intima-media thickness, stiffness, and CD4+ and CD8+ T-cell counts were observed. Conclusion: The first-line highly active antiretroviral therapy currently used in China is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients with good highly active antiretroviral therapy compliance. Human immunodeficiency virus may play a role in the development of atherosclerosis.
Documentos Relacionados
- Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy
- β-Blockers as first-line therapy for hypertension
- Factors associated to modification of first-line antiretroviral therapy due to adverse events in people living with HIV/AIDS
- Surgery should not be used as first-line treatment
- First-line drugs for hypertension