Lomofungin, an Inhibitor of Deoxyribonucleic Acid-Dependent Ribonucleic Acid Polymerases
AUTOR(ES)
Cano, F. R.
RESUMO
Lomofungin, an antibiotic active against fungi, yeasts, and bacteria, was found to be a potent inhibitor of purified Escherichia coli deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase. It prevents RNA synthesis by a direct interaction with the polymerase and not with the template or substrate; chain elongation is halted promptly. Three DNA-dependent RNA polymerases isolated from Saccharomyces strain 1016 were also sensitive to the antibiotic. Lomofungin does not appear to react generally with proteins, as bovine serum albumin did not prevent the inhibitory effect and numerous other enzymes were not affected by lomofungin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=444488Documentos Relacionados
- Nuclear Deoxyribonucleic Acid-Dependent Ribonucleic Acid Polymerases from Saccharomyces cerevisiae
- Deoxyribonucleic Acid-Dependent Ribonucleic Acid Polymerase of Caulobacter crescentus
- Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase in Visna Virus
- FURTHER STUDIES ON DEOXYRIBONUCLEIC ACID-DEPENDENT ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID*
- DEOXYRIBONUCLEIC ACID-DEPENDENT INCORPORATION OF NUCLEOTIDES FROM NUCLEOSIDE TRIPHOSPHATES INTO RIBONUCLEIC ACID*
