Light affects cAMP signaling and cell movement activity in Dictyostelium discoideum
AUTOR(ES)
Miura, Kota
FONTE
The National Academy of Sciences
RESUMO
The multicellular, slug stage of the slime mould Dictyostelium discoideum lacks specific sensory cells and organs but can nevertheless respond in a very sensitive manner to external stimuli such as temperature and light. Within the migrating slug, the behavior of up to 100,000 individual amoebae is coordinated by cAMP mediated cell–cell signaling and chemotaxis. We report here the striking result that light directly modulates the cAMP cell–cell signaling system. Light-induced secretion of cAMP from the slug tips decreased the period length of optical density waves and speeded up cell movement. A local effect of light on cAMP release within the slug tip could modulate cell movement within the slug and thus control its phototactic turning and orientation toward a light source.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=15762Documentos Relacionados
- cAMP and spore differentiation in Dictyostelium discoideum.
- Superinduction of the Dictyostelium discoideum cell surface cAMP receptor by pulses of cAMP.
- cAMP controls cytosolic Ca2+ levels in Dictyostelium discoideum
- Two cAMP receptors activate common signaling pathways in Dictyostelium.
- Disruption of Dictyostelium discoideum morphogenesis by overproduction of cAMP phosphodiesterase.
