Licanol, um novo flavanol, e outros constituintes de Licania macrophylla Benth
AUTOR(ES)
Medeiros, Fernando Antônio de, Medeiros, Alessandra A. N., Tavares, Josean Fechine, Barbosa Filho, José Maria, Lima, Edeltrudes de Oliveira, Silva, Marcelo Sobral da
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
The phytochemical investigation of L. macrophylla Benth led to the isolation of a new flavanol named licanol: (-)-4'-O-methyl-epigallocatechin-3'-O-α-L-rhamnoside, along with nine known compounds, identified as: (-)-4'-O-methyl-epigallocatechin, pheophytin A, 13²-hydroxy-(13²-S)-pheophytin A, pheophytin B, sitosterol, stigmasterol, sitosterol-β-O-glucoside, betulinic alcohol and oleanolic acid. The structures were established based on IR, HR-ESI-MS, and NMR spectrometric data analysis with the aid of 2D techniques. The methanolic extracts of leaves and stem bark as well as the compounds licanol, 13²-hidroxi-(13²-S)-feofitina A, and betulinic alcohol demonstrated antimicrobial activity against several bacterial strains.
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