Lesões proliferativas gastricas induzidas pelo refluxo duodeno-gastrico em ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

The participation of the duodenogastric reflux in the development of mucosal proliferation and in the process of gastric carcinogenesis it comes being researched during decades. Considering the divergences of the results obtained in the literature and the limited number of studies, we intended to evaluate the mucosal proliferation and its characteristics, thought specific models of duodenogastric reflux, in stomach of WISTAR rats. Healthy and male three months old rats were divided into 3 groups: group I - control (n = 25 animaIs), submitted to the gastrotomy in the posterior wall of the glandular stomach; group II - (n = 25 animaIs) submitted to duodenogastric reflux through the gastrojejunoanastomosis in the posterior wall of the glandular stomach and group m - (n = 25 animaIs) submitted to duodenogastric reflux through the pylorus after the same procedure of the group II,closing the afferent loop. The animaIs were observed during 36 weeks. Were analysed the mucosal damage, respectively, macroscopic and microscopic finding of the antrum, the gastrojejunostomy and the squamous area. The group I were not observed mucosa damage. The macroscopic lesions of the antrum in the groups II and III were 0% and 20%, respectively. The macroscopic lesions of the gastrojejunostomy in the groups II and III were 36% and 88%, respectively, in the squamous area were 12% and 28%, respectively. Microscopically, were diagnosed adenomatous hyperplasia (AR), squamous hyperplasia (SH) and adenocarcinoma (AC). The occurrence of AR at the antrum in the groups II and III were 0% and 40%, respectively, and in the gastrojejunostomy were 40% and 72%, respectively. The occurrence of SH at the squamous area in the groups II and III were 12% and 20%, respectively, without statistics differences between the groups. The AC were found in three animaIs of groups m (12%). The final conclusions showed that the duodenogastric reflux studied in the both groups (II/ III), presented mainly benign lesions in the gastric mucosal of the rats

ASSUNTO(S)

carcinogenese hiperplasia adenocarcinoma

ACESSO AO ARTIGO

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