Leptina: um modulador central das respostas imunes. / Leptin: a central modulator of imune responses.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

07/10/2011

RESUMO

Leptin is a mediator of both neuroendocrine and immune responses, and has been associated with several autoimmune diseases. Our objective was to study the importance of leptin in modulating the immune response in experimental transplantation, with emphasis on its role in the plasticity of T lymphocytes and dendritic cells (DC). We observed that animals leptin deficient had an increased skin graft survival and lower frequency of Th1 and increased regulatory (Treg), Th2 and Th17 T cells. Furthermore, naive CD4+ T cells differentiate more efficiently in Treg and Th17 cells, with DC and without DC, in the absence of leptin. Our data indicate that BMDC, mature and immature, is compromised in the absence of leptin, leading to less proliferation of CD4+ and increased generation / expansion of Treg cells, Th2 and Th17. Thus, the lack of leptin resulted in a predominance of Th2 and Treg T cells, which together with the profile of tolerogenic DC could be one of the mechanisms responsible for increased survival of allograft skin.

ASSUNTO(S)

immunology imunologia imunologia de transplantes leptin leptina skin transplantation transplantation immunology transplante de pele

ACESSO AO ARTIGO

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