Leishmaniose Visceral em pacientes infectados por HIV. Estudo de casos observados em Campo Grande, MS, 2000-2006. / Leishmaniasis Visceral in patients infected by HIV. Case studies observed in Campo Grande, MS, 2000-2006.

AUTOR(ES)

Priscilla Alexandrino de Oliveira

DATA DE PUBLICAÇÃO

2007

RESUMO

The outspread and urbanization of visceral leishmaniasis in Mato Grosso do Sul becoming the disease a public health problem in the state. To know the clinical and epidemiological characteristics of visceral leishmaniasis in HIV patients, a series of 23 patients attended in Campo Grande, center west region of Brazil, from 2000 to 2006, was studied. We selected the patients with HIV and bone marrow culture positive for leishmaniasis The median age of patients was 37 years (range 21-56), 87% were male, All the patients lived in Mato Grosso do Sul, 34.8 percent of patients had intravenous drug use as their HIV transmission category. The majority of patients had advanced HIV disease, 80 percent had CD4+T cells count less than 200 cells/mm3 and a median of 44.5 cells/mm3 during the first episode of visceral leishmaniasis. Despite of this fact, both diseases were diagnosed at the same time in 43 percent of the patients. All HIV infected patients with visceral leishmaniasis presented fever, 78 percent presented enlargement of the liver and spleen. The patients presented varying degrees of blood cytopenias and biochemical abnormalities. Diagnosis was also achieved in 87% of the patients with the detection of Leishmania amastigotes in Giemsa-stained smears from aspirates of bone marrow Five patients were treated only with meglumine antimoniate, four patients were treated with only amphotericin B and twelve patients were treated with both therapies. One or two relapses were seen in 56.7 percent of patients. Only one patient died due to leishmaniasis.

ASSUNTO(S)

leishmaniasis, visceral/epidemiology leishmaniose visceral/epidemiologia doencas infecciosas e parasitarias leishmaniose visceral/diagnostico hiv infections estudo de caso case study leishmaniasis, visceral/diagnosis infeccão por hiv

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