Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model
AUTOR(ES)
Medeiros Júnior, Jorge Luiz, Oliveira, Fabiana Araújo de, Silva, Pamella Campos, Furriel, Angélica, Sampaio, Francisco José Barcellos, Gregório, Bianca Martins
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2014
RESUMO
PURPOSE: To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats. METHODS: Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis. RESULTS: All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003). CONCLUSION: Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction.
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