KRAB-containing zinc-finger repressor proteins
AUTOR(ES)
Urrutia, Raul
FONTE
BioMed Central
RESUMO
The largest family of zinc-finger transcription factors comprises those containing the Krüppel-associated box (or KRAB domain). The KRAB domain behaves as a transcriptional repressor domain and the C2H2 zinc-finger motifs bind DNA. Members of the family are involved in maintenance of the nucleolus, cell differentiation, cell proliferation, apoptosis, and neoplastic transformation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=328446Documentos Relacionados
- Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.
- Design of polydactyl zinc-finger proteins for unique addressing within complex genomes
- Targeted mutagenesis using zinc-finger nucleases in Arabidopsis
- A novel four zinc-finger protein targeted against p190BcrAbl fusion oncogene cDNA: utilisation of zinc-finger recognition codes
- Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression
