Key antigenic determinants in regulation of the immune response.
AUTOR(ES)
Turkin, D
RESUMO
The immune response to beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23)is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein. A cyanogen bromide peptide of beta-galactosidase, CB2, mimics the suppression seen with the enzyme. It is time dependent, carrier specific, and anti-theta sensitive; however, this suppression is not preceded by a wave of help. It is possible that CB2 cannot stimulate helpers, and is only able to activate suppressor cells. These data indicate that one small region of an antigen, capable of activating suppressors, can nullify the positive effect induced in helper T cells reactive with other epitopes on beta-galactosidase. Key determinants on macromolecules may in this way be influential in regulating the immune response to the entire antigen molecule.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=431811Documentos Relacionados
- Molecular determinants of immunogenicity: the immunon model of immune response.
- Branhamella catarrhalis: epidemiology, surface antigenic structure, and immune response.
- Relationship between antigenic stimulation and increased splenic peroxidase levels during the immune response.
- Clonal sketches of the immune response.
- Lack of immune deficiency in sarcoidosis: compartmentalisation of the immune response.
