Isolation and analysis of inhibitors of transposon Tn3 site-specific recombination.
AUTOR(ES)
Fennewald, M A
RESUMO
We have constructed a genetic bioassay for inhibitors of site-specific recombination by transposon Tn3 resolvase. Of 6,000 compounds tested, 26 inhibited in vivo, and 5 of these 26 inhibited in vitro. At least two inhibitors also inhibit the topoisomerase of resolvase. We have also identified analogs of A1062 which inhibit.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=215648Documentos Relacionados
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