Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)

AUTOR(ES)

Lianza, Mariacaterina; Verdan, Maria Helena; Andrade, Jean Paulo de; Poli, Ferruccio; Almeida, Larissa C. de; Costa-Lotufo, Leticia V.; Cunha Neto, Álvaro; Oliveira, Sarah C. C.; Bastida, Jaume; Batista, Andrea N. L.; Batista Jr., João M.; Borges, Warley S.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2020-10

RESUMO

The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity.

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