Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae)
AUTOR(ES)
Santana, Jeferson S., Sartorelli, Patricia, Lago, João Henrique G., Matsuo, Alisson L.
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius.In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive.
Documentos Relacionados
- Constituíntes fenólicos polares de Schinus terebinthifolius Raddi (Anacardiaceae)
- Estrutura e desenvolvimento de canais secretores em frutos de Schinus terebinthifolius Raddi (Anacardiaceae)
- Schinus terebinthifolius raddi (anacardiaceae) no processo de cicatrização de gastrorrafias em ratos
- Ontogeny and Structure of the Pericarp of Schinus terebinthifolius Raddi (Anacardiaceae)
- Biologia floral e fenologia reprodutiva de Schinus terebinthifolius Raddi (Anacardiaceae) em Restinga do Norte Fluminense
