Is there a role for Notch signalling in human breast cancer?
AUTOR(ES)
Brennan, Keith
FONTE
BioMed Central
RESUMO
Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=154142Documentos Relacionados
- Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?
- Wnt signalling via the epidermal growth factor receptor: a role in breast cancer?
- Lactation and cancer risk: is there a relation specific to breast cancer?
- Is there an association between thyroid function abnormalities and breast cancer?
- Is There Any Cardiovascular Concern Regarding the Use of Aromatase Inhibitors in Breast Cancer?
