Is the colon mucosa affected by ten days of gastric restriction in an animal model?

AUTOR(ES)

Akamatsu, Flávia Emi

FONTE

Acta Cir. Bras.

DATA DE PUBLICAÇÃO

19/08/2019

RESUMO

Abstract Purpose To identify whether the colon mucosa is affected by ten days of gastric restriction in an animal model. Methods An experimental model of gastric restriction was devised using rats. The animals were submitted to surgical gastrostomy, and a cylindrical loofah was inserted into the stomach. We studied 30 adult male Wistar rats divided into three groups: the stomach restriction group (R10); the sham group (S10), which underwent the same procedure except for the loofah insertion; and the control group (C10). The expression of neutral and acid mucins was evaluated using histochemical techniques. Goblet cells and protein content were compared between groups using generalized estimation equations (GEEs). Bonferroni’s multiple comparison was applied to identify differences between the groups. All tests considered a 5% significance level. Results There was an increased expression of neutral mucins, acid mucins and goblet cells in the R10 group. Collagen was also enhanced in the R10 group. Conclusion The colon mucosa is affected by ten days of gastric restriction in an animal model, increasing neutral mucins, acid mucins and collagen content with trophic maintenance.

Documentos Relacionados

• Is it time to modify the reverse cholesterol transport model?
• Predicting the progress of colon cancer by DNA methylation markers of the p16 gene in feces - Evidence from an animal model
• Morphological and pathological changes of Eustachian tube mucosa in an animal model of eosinophilic otitis media
• Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.
• Can leaf area in rice be defined by a mathematical model?