Is phototridachiahydropyrone a true natural product?

AUTOR(ES)

Gavagnin, Margherita, Mollo, Ernesto, Cimino, Guido

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

2015-12

RESUMO

Abstract The occurrence of (−)-phototridachiahydropyrone (5) in nature has been proven. This compound has been now identified as minor component of the extract of marine sacoglossan mollusk Elysia crispata from which the main (−)-tridachiahydropyrone (4) was previously described. Synthetic (±)-5 was formerly obtained by Moses’ group by biomimetic photochemical conversion of (±)-tridachiahydropyrone (4). The same authors suggested that compound 5 had to be a natural product derived from precursor 4 “yet to be discovered”. Comparison of CD profiles of natural (−)-4 and (−)-5 indicated the same absolute configuration for both compounds. This evidence is in agreement with the concerted mechanism proposed for the photochemical conversion.

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