Irresistible IRES: Attracting the translation machinery to internal ribosome entry sites

AUTOR(ES)

Vagner, Stéphan

FONTE

Oxford University Press

RESUMO

Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.

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