Iodine nutritional status in Brazil: a meta-analysis of all studies performed in the country pinpoints to an insufficient evaluation and heterogeneity
AUTOR(ES)
Campos, Renata de Oliveira, Barreto, Iasmin dos Santos, Maia, Lorena Rejane de Jesus, Rebouças, Sara Cristina Lima, Cerqueira, Taíse Lima de Oliveira, Oliveira, Clotilde Assis, Santos, Carlos Antônio de Souza Teles, Mendes, Carlos Maurício Cardeal, Teixeira, Leonardo Sena Gomes, Ramos, Helton Estrela
FONTE
Arch. Endocrinol. Metab.
DATA DE PUBLICAÇÃO
2015-02
RESUMO
Objectives Iodine deficiency disorder (IDD) is the result of an inadequate dietary intake of iodine, which physiological consequences are endemic goiter and thyroid dysfunction. The objective of this study was to a analyze studies that assessed the status of Brazil’s population iodine nutrition and IDD prevalence. Materials and methods Systematic review using PRISMA statement. Electronic database: PubMed, Medline, SciELO and Lilacs. Quality of studies: Newcastle-Ottawa Scale. Meta-analysis was carried out with R Core Team Statistical Software, version 3.1.0 (2014). The summary measure (WMD) and its confidence interval (CI) of 95% were calculated. The “Funnel plot” graph assessed publication bias and heterogeneity. Results Seventeen papers were eligible: pregnant women (2), school children (9), adults/elderly (4) and preschool children/infants (2). Geographic distribution: North (1), Northeast (1), Midwest (2), Southeast (13), South (3). Twenty-three thousand two hundred seventy-two subjects were evaluated between 1997 and 2013 and all have use urinary iodine (UI) measurement. However, only 7 studies could be included in meta-analysis, all from Southeast region. The overall prevalence of IDD in school children in southeast region was 15.3% (95% CI, 13-35%), however this data had an important heterogeneity, expressed by the I2 Statistic of 99.5%. Conclusion Only few studies have been performed and enrolled populations from south/southeast region of Brazil. The actual IDD prevalence analysis is complex because it was detected bias due influence of individual studies and very high heterogeneity. IDD might still be high in some areas but this remained unknown even after this meta-analysis evaluation. The generation of a national program for analysis of iodine status in all regions is urgently required. Arch Endocrinol Metab. 2015;59(1):13-22
Documentos Relacionados
- Analysis of neonatal mortality risk factors in Brazil: a systematic review and meta-analysis of observational studies
- Probiotics for broiler chickens in Brazil: systematic review and meta-analysis
- Mental health problems among medical students in Brazil: a systematic review and meta-analysis
- Application of meta-analysis in reviewing occupational cohort studies.
- Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis