Investigation of the solid state properties of amoxicillin trihydrate and the effect of powder pH
AUTOR(ES)
Ghassempour, Alireza
FONTE
Springer-Verlag
RESUMO
The purpose of this research was to investigate some physicochemical and solid-state properties of amoxicillin trihydrate (AMT) with different powder pH within the pharmacopoeia-specified range. AMT batches prepared using Dane salt method with the pH values from 4.39 to 4.97 were subjected to further characterization studies. Optical and scanning electron microscopy showed that different batches of AMT powders were similar in crystal habit, but the length of the crystals increased as the pH increased. Further solid-state investigations using powder x-ray diffraction (PXRD) demonstrated the same PXRD pattern, but the intensity of the peaks raised by the powder pH, indicated increased crystallinity. Differential scanning calorimetry (DSC) studies further confirmed that as the powder pH increased, the crystallinity and, hence, thermal stability of AMT powders increased. Searching for the possible cause of the variations in the solid state properties, HPLC analysis showed that despite possessing the requirements of the United States Pharmacopoeia (USP) for purity/impurity profile, there was a direct relationship between the increase of the powder pH and the purity of AMT, and also decrease in the impurity I (α-Hydroxyphenylglycine) concentration in AMT powder. Recrystallization studies confirmed that the powder pH could be controlled by adjusting the pH of the crystallization.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2750679Documentos Relacionados
- Solid-state fluorescence of the trihydrate phases of ampicillin and amoxicillin
- Effects of pH and cholesterol on DMPA membranes: a solid state 2H- and 31P-NMR study.
- Effect of the growth of anaerobic bacteria on the surface pH of solid media.
- Effects of pH and salinity on the antimicrobial properties of clavanins.
- Antimicrobial Effect of Simple Lipids and the Effect of pH and Positive Ions