Introns in Cryptococcus

AUTOR(ES)

Janbon, Guilhem

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

19/02/2018

RESUMO

In Cryptococcus neoformans, nearly all genes are interrupted by small introns. In recent years, genome annotation and genetic analysis have illuminated the major roles these introns play in the biology of this pathogenic yeast. Introns are necessary for gene expression and alternative splicing can regulate gene expression in response to environmental cues. In addition, recent studies have revealed that C. neoformans introns help to prevent transposon dissemination and protect genome integrity. These characteristics of cryptococcal introns are probably not unique to Cryptococcus, and this yeast likely can be considered as a model for intron-related studies in fungi.

Documentos Relacionados

• Periodicities in introns.
• Creatinine metabolism in Cryptococcus neoformans and Cryptococcus bacillisporus.
• Unexpected abundance of self-splicing introns in the genome of bacteriophage Twort: Introns in multiple genes, a single gene with three introns, and exon skipping by group I ribozymes
• Introns increase transcriptional efficiency in transgenic mice.
• Origins of recently gained introns in Caenorhabditis