Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage of Streptococcus pneumoniae

AUTOR(ES)

Briles, David E.

FONTE

American Society for Microbiology

RESUMO

Acquisition of pneumococci is generally from carriers rather than from infected individuals. Therefore, to induce herd immunity against Streptococcus pneumoniae it will be necessary to elicit protection against carriage. Capsular polysaccharide-protein conjugates, PspA, and PsaA are known to elicit some protection against nasopharyngeal carriage of pneumococci but do not always completely eliminate carriage. In this study, we observed that PsaA elicited better protection than did PspA against carriage. Pneumolysin elicited no protection against carriage. Immunization with a mixture of PsaA and PspA elicited the best protection against carriage. These results indicate that PspA and PsaA may be useful for the elicitation of herd immunity in humans. As PspA and pneumolysin are known to elicit immunity to bacteremia and pneumonia, their inclusion in a mucosal vaccine may enable such a vaccine to prevent invasive disease as well as carriage.

Documentos Relacionados

• Cloning, expression and purification of proteins of surface, PsaA and fragments of PspA from Streptococcus pneumoniae
• Estudo do efeito adjuvante de CTB em fusões com as proteínas pneumocócicas PsaA e PspA no desenvolvimento de vacinas protéicas contra Streptococcus pneumoniae
• Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection.
• Differential PsaA-, PspA-, PspC-, and PdB-Specific Immune Responses in a Mouse Model of Pneumococcal Carriage
• Genetic Immunization with the Region Encoding the α-Helical Domain of PspA Elicits Protective Immunity against Streptococcus pneumoniae