Intrahippocampal Wortmannin Infusion Enhances Long-Term Spatial and Contextual Memories

AUTOR(ES)

Dash, Pramod K.

FONTE

Cold Spring Harbor Laboratory Press

RESUMO

The transition from short- to long-term memory involves several biochemical cascades, some of which act in an antagonistic manner. Post-training intrahippocampal administration of wortmannin, a pharmacological inhibitor of phosphatidylinositol 3-kinase, had no effect on memory tested 3 h later, but improved long-term memory tested 48 h following the completion of training. This effect was seen in two hippocampus-dependent tasks: the Morris water maze, using both massed and distributed training paradigms, and contextual fear conditioning. The improvement of long-term memory appears to be the result of enhanced consolidation, as wortmannin had no effect on memory recall. These results are consistent with the hypothesis that memory consolidation involves competing processes, and that blockade of an inhibitory constraint facilitates the consolidation process.

Documentos Relacionados

• Long-term potentiation and long-term depression: a clinical perspective
• Running enhances neurogenesis, learning, and long-term potentiation in mice
• Long-term changes in hippocampal physiology and learning ability of rats after intrahippocampal tetanus toxin.
• 6S RNA Function Enhances Long-Term Cell Survival
• Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition